Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells.

Leukotriene D4 and interleukin-13 cooperate to increase the release of eotaxin-3 by airway epithelial cells.

Airway epithelial cells play a central role in the physiopathology of asthma. They release eotaxins when treated with T(H)2 cytokines such as interleukin (IL)-4 or IL-13, and these chemokines attract eosinophils and potentiate the biosynthesis of cysteinyl leukotrienes (cysLTs), which in turn induce...

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Bibliographic Details
Main Authors: Véronique Provost, Anick Langlois, François Chouinard, Marek Rola-Pleszczynski, Jamila Chakir, Nicolas Flamand, Michel Laviolette
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3432028?pdf=render

Internet

http://europepmc.org/articles/PMC3432028?pdf=render

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