Galectin-9 Induces Mitochondria-Mediated Apoptosis of Esophageal Cancer In Vitro and In Vivo in a Xenograft Mouse Model

Galectin-9 Induces Mitochondria-Mediated Apoptosis of Esophageal Cancer In Vitro and In Vivo in a Xenograft Mouse Model

Galectin-9 (Gal-9) enhances tumor immunity mediated by T cells, macrophages, and dendritic cells. Its expression level in various cancers correlates with prognosis. Furthermore, Gal-9 directly induces apoptosis in various cancers; however, its mechanism of action and bioactivity has not been clarifi...

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Bibliographic Details
Main Authors: Taiga Chiyo, Koji Fujita, Hisakazu Iwama, Shintaro Fujihara, Tomoko Tadokoro, Kyoko Ohura, Takanori Matsui, Yasuhiro Goda, Nobuya Kobayashi, Noriko Nishiyama, Tatsuo Yachida, Asahiro Morishita, Hideki Kobara, Hirohito Mori, Toshiro Niki, Mitsuomi Hirashima, Takashi Himoto, Tsutomu Masaki
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:International Journal of Molecular Sciences
Subjects:
galectin-9
apoptosis
esophageal squamous cell carcinoma
JNK
microRNA
Online Access:https://www.mdpi.com/1422-0067/20/11/2634

Internet

https://www.mdpi.com/1422-0067/20/11/2634

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