CTCF and cohesin regulate chromatin loop stability with distinct dynamics

CTCF and cohesin regulate chromatin loop stability with distinct dynamics

Folding of mammalian genomes into spatial domains is critical for gene regulation. The insulator protein CTCF and cohesin control domain location by folding domains into loop structures, which are widely thought to be stable. Combining genomic and biochemical approaches we show that CTCF and cohesin...

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Bibliographic Details
Main Authors: Anders S Hansen, Iryna Pustova, Claudia Cattoglio, Robert Tjian, Xavier Darzacq
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
CTCF
cohesin
genome organization
biophysics
single-molecule
imaging
Online Access:https://elifesciences.org/articles/25776

Internet

https://elifesciences.org/articles/25776

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