CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis

CXCL13/CXCR5 signalling is pivotal to preserve motor neurons in amyotrophic lateral sclerosis

Background: CXCL13 is a B and T lymphocyte chemokine that mediates neuroinflammation through its receptor CXCR5. This chemokine is highly expressed by motoneurons (MNs) in Amyotrophic Lateral Sclerosis (ALS) SOD1G93A (mSOD1) mice during the disease, particularly in fast-progressing mice. Accordingly...

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Bibliographic Details
Main Authors: Maria Chiara Trolese, Alessandro Mariani, Mineko Terao, Massimiliano de Paola, Paola Fabbrizio, Francesca Sironi, Mami Kurosaki, Silvia Bonanno, Silvia Marcuzzo, Pia Bernasconi, Francesca Trojsi, Eleonora Aronica, Caterina Bendotti, Giovanni Nardo
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:EBioMedicine
Subjects:
Amyotrophic lateral sclerosis
SOD1G93A mice
Motor neurons
Immune response
Chemokines
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420304734

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http://www.sciencedirect.com/science/article/pii/S2352396420304734

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