Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo

Combined Targeting of AKT and mTOR Inhibits Proliferation of Human NF1-Associated Malignant Peripheral Nerve Sheath Tumour Cells In Vitro but not in a Xenograft Mouse Model In Vivo

Persistent signalling via the PI3K/AKT/mTOR pathway is a major driver of malignancy in NF1-associated malignant peripheral nerve sheath tumours (MPNST). Nevertheless, single targeting of this pathway is not sufficient to inhibit MPNST growth. In this report, we demonstrate that combined treatment wi...

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Bibliographic Details
Main Authors: Alexander Schulte, Florian Ewald, Melanie Spyra, Daniel J. Smit, Wei Jiang, Johannes Salamon, Manfred Jücker, Victor-Felix Mautner
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
mpnst
targeted therapy
akt
neurofibromatosis type 1
signaling
xenograft model
Online Access:https://www.mdpi.com/1422-0067/21/4/1548

Internet

https://www.mdpi.com/1422-0067/21/4/1548

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