Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress.

Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress.

Master regulator protein p53, popularly known as the "guardian of genome" is the hub for regulation of diverse cellular pathways. Depending on the cell type and severity of DNA damage, p53 protein mediates cell cycle arrest or apoptosis, besides activating DNA repair, which is apparently a...

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Bibliographic Details
Main Authors: Nidhi Bansal, Rama Kadamb, Shilpi Mittal, Leena Vig, Raisha Sharma, Bilikere S Dwarakanath, Daman Saluja
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3197607?pdf=render

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http://europepmc.org/articles/PMC3197607?pdf=render

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