Short-term therapy with simvastatin reduces inflammatory mediators and heart inflammation during the acute phase of experimental Chagas disease

Short-term therapy with simvastatin reduces inflammatory mediators and heart inflammation during the acute phase of experimental Chagas disease

Trypanosoma cruzi infection induces progressive cardiac inflammation that leads to fibrosis and modifications in the heart architecture and functionality. Statins, such as 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, have been studied due to their pleiotropic roles in modula...

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Bibliographic Details
Main Authors: Rafael Rodrigues Silva, Deena Shrestha-Bajracharya, Camila Megale Almeida-Leite, Rômulo Leite, Maria Terezinha Bahia, Andre Talvani
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2012-06-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Chagas cardiomyopathy
Trypanosoma cruzi
simvastatin
chemokines
inflammation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000400012&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762012000400012&lng=en&tlng=en

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