M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry

M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry

Summary: Macrophage plasticity is essential for innate immunity, but in-depth signaling mechanism(s) regulating their functional phenotypes are ill-defined. Here we report that interferon (IFN) γ priming of naive macrophages induces store-mediated Ca2+ entry and inhibition of Ca2+ entry impairs pola...

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Bibliographic Details
Main Authors: Arun Chauhan, Yuyang Sun, Pramod Sukumaran, Fredice O. Quenum Zangbede, Christopher N. Jondle, Atul Sharma, Dustin L. Evans, Pooja Chauhan, Randolph E. Szlabick, Mary O. Aaland, Lutz Birnbaumer, Jyotika Sharma, Brij B. Singh, Bibhuti B. Mishra
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004218301494

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http://www.sciencedirect.com/science/article/pii/S2589004218301494

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