Pharmacogenomics of Methotrexate Membrane Transport Pathway: Can Clinical Response to Methotrexate in Rheumatoid Arthritis Be Predicted?

Pharmacogenomics of Methotrexate Membrane Transport Pathway: Can Clinical Response to Methotrexate in Rheumatoid Arthritis Be Predicted?

Background: Methotrexate (MTX) is widely used for rheumatoid arthritis (RA) treatment. Single nucleotide polymorphisms (SNPs) could be used as predictors of patients’ therapeutic outcome variability. Therefore, this study aims to evaluate the influence of SNPs in genes encoding for MTX membrane tran...

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Bibliographic Details
Main Authors: Aurea Lima, Miguel Bernardes, Rita Azevedo, Rui Medeiros, Vítor Seabra
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:International Journal of Molecular Sciences
Subjects:
ATP-binding cassette
clinical response
genetic risk index
methotrexate
polymorphisms
rheumatoid arthritis
solute carriers
transporters
Online Access:http://www.mdpi.com/1422-0067/16/6/13760

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http://www.mdpi.com/1422-0067/16/6/13760

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