Inhibition of Heme Oxygenase-1 Activity Enhances Wilms Tumor-1-Specific T-Cell Responses in Cancer Immunotherapy

Inhibition of Heme Oxygenase-1 Activity Enhances Wilms Tumor-1-Specific T-Cell Responses in Cancer Immunotherapy

Wilms tumor protein-1 (WT1) is an attractive target for adoptive T-cell therapy due to its expression in solid tumors and hematologic malignancies. However, T cells recognizing WT1 occur in low frequencies in the peripheral blood of healthy donors, limiting potential therapeutic possibilities. Tin m...

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Bibliographic Details
Main Authors: Damaris A. Schillingmann, Sebastian B. Riese, Vijith Vijayan, Sabine Tischer-Zimmermann, Helga Schmetzer, Britta Maecker-Kolhoff, Rainer Blasczyk, Stephan Immenschuh, Britta Eiz-Vesper
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
Antigen-specific T cells
heme oxygenase 1 (HO-1) inhibition
immunotherapy
Wilms tumor protein-1 (WT1), acute myeloid leukemia (AML)
Online Access:https://www.mdpi.com/1422-0067/20/3/482

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https://www.mdpi.com/1422-0067/20/3/482

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