Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice

Hypothermia mediates age-dependent increase of tau phosphorylation in db/db mice

Accumulating evidence from epidemiological studies suggest that type 2 diabetes is linked to an increased risk of Alzheimer's disease (AD). However, the consequences of type 2 diabetes on AD pathologies, such as tau hyperphosphorylation, are not well understood. Here, we evaluated the impact of...

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Bibliographic Details
Main Authors: Noura B. El Khoury, Maud Gratuze, Franck Petry, Marie-Amélie Papon, Carl Julien, François Marcouiller, Françoise Morin, Samantha B. Nicholls, Frédéric Calon, Sébastien S. Hébert, André Marette, Emmanuel Planel
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Diabetes mellitus
db/db mice
Tau hyperphosphorylation
Hippocampus
Kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116300055

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http://www.sciencedirect.com/science/article/pii/S0969996116300055

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