Cardiolipin-mediated PPARγ S112 phosphorylation impairs IL-10 production and inflammation resolution during bacterial pneumonia

Cardiolipin-mediated PPARγ S112 phosphorylation impairs IL-10 production and inflammation resolution during bacterial pneumonia

Summary: Bacterial pneumonia is a global healthcare burden, and unwarranted inflammation is suggested as an important cause of mortality. Optimum levels of the anti-inflammatory cytokine IL-10 are essential to reduce inflammation and improve survival in pneumonia. Elevated levels of the mitochondria...

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Bibliographic Details
Main Authors: Mayank Garg, Saumya Johri, Shakti Sagar, Aniruddha Mundhada, Anurag Agrawal, Prabir Ray, Krishnendu Chakraborty
Format: Article
Language:English
Published: Elsevier 2021-02-01
Series:Cell Reports
Subjects:
mitochondrial-DAMP
cardiolipin
lung inflammation resolution
PPARγ
IL-10
pneumonia
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721000498

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http://www.sciencedirect.com/science/article/pii/S2211124721000498

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