Restoration of spermatogenesis and male fertility using an androgen receptor transgene.

Androgens signal through the androgen receptor (AR) to regulate male secondary sexual characteristics, reproductive tract development, prostate function, sperm production, bone and muscle mass as well as body hair growth among other functions. We developed a transgenic mouse model in which endogenou...

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Bibliographic Details
Main Authors: William H Walker, Evan Easton, Rebecca S Moreci, Corey Toocheck, Prashanth Anamthathmakula, Pancharatnam Jeyasuria
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4372537?pdf=render