Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway

Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1/AMPKα/SREBP1 signaling pathway

Abstract Background Nonalcoholic fatty liver disease is one of the most common liver diseases in the world and is a typical hepatic manifestation of metabolic syndrome which is characterized with lipid accumulation in liver. Nicotinamide phosphoribosyltransferase (NAMPT) has been recently identified...

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Bibliographic Details
Main Authors: Ling-Fang Wang, Xiao-Nv Wang, Cong-Cong Huang, Long Hu, Yun-Fei Xiao, Xiao-Hui Guan, Yi-Song Qian, Ke-Yu Deng, Hong-Bo Xin
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Lipids in Health and Disease
Subjects:
Nampt
Nad+
Nafld
FK866
Sirt1
AMPKα
Online Access:http://link.springer.com/article/10.1186/s12944-017-0464-z

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http://link.springer.com/article/10.1186/s12944-017-0464-z

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