Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells
Enhanced Wnt receptor activity is a major cause of cancer development. Here the authors identify camelid single-domain antibody fragments (VHHs) that bind to the Wnt receptor LRP5/6 ectodomain, determine the crystal structures and show that these VHHs selectively inhibit Wnt3- mediated cellular resp...
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Bibliographic Details
| Main Authors: |
Nicola Fenderico,
Revina C. van Scherpenzeel,
Michael Goldflam,
Davide Proverbio,
Ingrid Jordens,
Tomica Kralj,
Sarah Stryeck,
Tarek Z. Bass,
Guy Hermans,
Christopher Ullman,
Teodor Aastrup,
Piet Gros,
Madelon M. Maurice |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-08172-z
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