Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

Anti-LRP5/6 VHHs promote differentiation of Wnt-hypersensitive intestinal stem cells

Enhanced Wnt receptor activity is a major cause of cancer development. Here the authors identify camelid single-domain antibody fragments (VHHs) that bind to the Wnt receptor LRP5/6 ectodomain, determine the crystal structures and show that these VHHs selectively inhibit Wnt3- mediated cellular resp...

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Bibliographic Details
Main Authors: Nicola Fenderico, Revina C. van Scherpenzeel, Michael Goldflam, Davide Proverbio, Ingrid Jordens, Tomica Kralj, Sarah Stryeck, Tarek Z. Bass, Guy Hermans, Christopher Ullman, Teodor Aastrup, Piet Gros, Madelon M. Maurice
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08172-z

Internet

https://doi.org/10.1038/s41467-018-08172-z

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