Development and Application of Performance Assessment Criteria for Next-Generation Sequencing-Based HIV Drug Resistance Assays

Development and Application of Performance Assessment Criteria for Next-Generation Sequencing-Based HIV Drug Resistance Assays

Next-generation sequencing (NGS)-based HIV drug resistance (HIVDR) assays outperform conventional Sanger sequencing in scalability, sensitivity, and quantitative detection of minority resistance variants. Thus far, HIVDR assays have been applied primarily in research but rarely in clinical settings....

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Bibliographic Details
Main Authors: Michael G. Becker, Dun Liang, Breanna Cooper, Yan Le, Tracy Taylor, Emma R. Lee, Sutan Wu, Paul Sandstrom, Hezhao Ji
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Viruses
Subjects:
HIV
drug resistance
test
assay
next-generation sequencing
validation
Online Access:https://www.mdpi.com/1999-4915/12/6/627

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https://www.mdpi.com/1999-4915/12/6/627

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