Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for prophylactic and therapeutic intervention of mucosal...

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Bibliographic Details
Main Authors: Jemima Ho, Xuexin Yang, Spyridoula-Angeliki Nikou, Nessim Kichik, Andrew Donkin, Nicole O. Ponde, Jonathan P. Richardson, Remi L. Gratacap, Linda S. Archambault, Christian P. Zwirner, Celia Murciano, Rhonda Henley-Smith, Selvam Thavaraj, Christopher J. Tynan, Sarah L. Gaffen, Bernhard Hube, Robert T. Wheeler, David L. Moyes, Julian R. Naglik
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09915-2

Internet

https://doi.org/10.1038/s41467-019-09915-2

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