CCL1 blockade alleviates human mesenchymal stem cell (hMSC)-induced pulmonary fibrosis in a murine sclerodermatous graft-versus-host disease (Scl-GVHD) model

CCL1 blockade alleviates human mesenchymal stem cell (hMSC)-induced pulmonary fibrosis in a murine sclerodermatous graft-versus-host disease (Scl-GVHD) model

Abstract Background Human chronic graft-versus-host disease (CGVHD) shares clinical characteristics with a murine sclerodermatous GVHD (Scl-GVHD, B10.D2 → BALB/c) model that is characterized by skin and lung fibrosis. In this study, bone marrow- or adipose tissue-derived human mesenchymal stem cells...

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Bibliographic Details
Main Authors: Ji-Young Lim, Da-Bin Ryu, Tae Woo Kim, Sung-Eun Lee, Gyeongsin Park, Hyoung Kyu Yoon, Chang-Ki Min
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Chronic graft-versus-host disease
Sclerodermatous graft-versus-host disease
Allogeneic hematopoietic stem cell transplantation
Online Access:http://link.springer.com/article/10.1186/s13287-020-01768-7

Internet

http://link.springer.com/article/10.1186/s13287-020-01768-7

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