Malarial hemozoin is a Nalp3 inflammasome activating danger signal.

Malarial hemozoin is a Nalp3 inflammasome activating danger signal.

BACKGROUND: Characteristic symptoms of malaria include recurrent fever attacks and neurodegeneration, signs that are also found in patients with a hyperactive Nalp3 inflammasome. Plasmodium species produce a crystal called hemozoin that is generated by detoxification of heme after hemoglobin degrada...

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Bibliographic Details
Main Authors: Catherine Dostert, Greta Guarda, Jackeline F Romero, Philippe Menu, Olaf Gross, Aubry Tardivel, Mario-Luca Suva, Jean-Christophe Stehle, Manfred Kopf, Ivan Stamenkovic, Giampietro Corradin, Jurg Tschopp
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2714977?pdf=render

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http://europepmc.org/articles/PMC2714977?pdf=render

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