T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1

T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1

T lymphocytes activated by dendritic cells (DC) which present tumor antigens play a key role in the antitumor immune response. However, in patients suffering from active cancer, DC are not efficient at initiating and supporting immune responses as they participate to T lymphocyte inhibition. DC in t...

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Bibliographic Details
Main Authors: Malika Trad, Alexandrine Gautheron, Jennifer Fraszczak, Darya Alizadeh, Claire Larmonier, Collin J. LaCasse, Sara Centuori, Sylvain Audia, Maxime Samson, Marion Ciudad, Francis Bonnefoy, Stéphanie Lemaire-Ewing, Emmanuel Katsanis, Sylvain Perruche, Philippe Saas, Bernard Bonnotte
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2015/891236

Internet

http://dx.doi.org/10.1155/2015/891236

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