Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation

Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation

Glioblastoma is the most common malignant brain tumour in adults. The failure of current therapies can be ascribed to glioma stem cells (GSCs), which can rapidly repopulate the tumour following the initial treatment. The study of histone deacetylase inhibitors, such as valproic acid (VPA), is becomi...

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Bibliographic Details
Main Authors: Gabriele Riva, Chiara Cilibrasi, Riccardo Bazzoni, Massimiliano Cadamuro, Caterina Negroni, Valentina Butta, Mario Strazzabosco, Leda Dalprà, Marialuisa Lavitrano, Angela Bentivegna
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Genes
Subjects:
glioma stem cells
valproic acid
Wnt/β-catenin signalling pathway
cell proliferation
cell invasion
Online Access:https://www.mdpi.com/2073-4425/9/11/522

Internet

https://www.mdpi.com/2073-4425/9/11/522

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