Arsenic sulfide promotes apoptosis in retinoid acid resistant human acute promyelocytic leukemic NB4-R1 cells through downregulation of SET protein.

Arsenic sulfide promotes apoptosis in retinoid acid resistant human acute promyelocytic leukemic NB4-R1 cells through downregulation of SET protein.

Tetra-arsenic tetra-sulfide (As4S4) is an arsenic compound with anti-tumor activity, especially in acute promyelocytic leukemia (APL) that are resistant to retinoic acid (RA). Although recent studies revealed that the therapeutic action of As4S4 is closely associated with the induction of cellular a...

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Bibliographic Details
Main Authors: Yuwang Tian, Yanfeng Liu, Pengcheng He, Feng Liu, Naicen Zhou, Xiaoyan Cheng, Lili Shi, Huachao Zhu, Jing Zhao, Yuan Wang, Mei Zhang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3890287?pdf=render

Internet

http://europepmc.org/articles/PMC3890287?pdf=render

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