Lack of Prenylated Proteins, Autophagy Impairment and Apoptosis in SH-SY5Y Neuronal Cell Model of Mevalonate Kinase Deficiency

Lack of Prenylated Proteins, Autophagy Impairment and Apoptosis in SH-SY5Y Neuronal Cell Model of Mevalonate Kinase Deficiency

Background/Aims: Mevalonate Kinase Deficiency (MKD), is a hereditary disease due to mutations in mevalonate kinase gene (MVK). MKD has heterogeneous clinical phenotypes: the correlation between MVK mutations and MKD clinical phenotype is still to be fully elucidated. Deficiency of prenylated protein...

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Bibliographic Details
Main Authors: Paola Maura Tricarico, Alessandra Romeo, Rossella Gratton, Sergio Crovella, Fulvio Celsi
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Mevalonate Kinase
Mevalonate Kinase Deficiency
Autophagy
Apoptosis
LC-3
Rho-A
Prenylation
GFP
Online Access:http://www.karger.com/Article/FullText/471235

Internet

http://www.karger.com/Article/FullText/471235

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