Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with <i>DMD</i> Deletion

Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with <i>DMD</i> Deletion

Whole-genome doubling is the second most frequent genomic event, after <i>TP53</i> alterations, in advanced solid tumors and is associated with poor prognosis. Tetraploidization step will lead to aneuploidy and chromosomic rearrangements. The mechanism leading to tetraploid cells is impo...

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Bibliographic Details
Main Authors: Candice Merle, Noémie Thébault, Sophie LeGuellec, Jessica Baud, Gaëlle Pérot, Tom Lesluyes, Lucile Delespaul, Lydia Lartigue, Frédéric Chibon
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
cell fusion
genomic instability
sarcoma
dystrophin
Online Access:https://www.mdpi.com/2072-6694/12/5/1281

Internet

https://www.mdpi.com/2072-6694/12/5/1281

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