CCR2 Deficiency Impairs Ly6Clo and Ly6Chi Monocyte Responses in Orientia tsutsugamushi Infection

CCR2 Deficiency Impairs Ly6Clo and Ly6Chi Monocyte Responses in Orientia tsutsugamushi Infection

Orientia (O.) tsutsugamushi, the causative agent of scrub typhus, is a neglected, obligate intracellular bacterium that has a prominent tropism for monocytes and macrophages. Complications often involve the lung, where interstitial pneumonia is a typical finding. The severity of scrub typhus in huma...

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Bibliographic Details
Main Authors: Michael Petermann, Zacharias Orfanos, Julie Sellau, Mohammad Gharaibeh, Hannelore Lotter, Bernhard Fleischer, Christian Keller
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
inflammatory monocytes
scrub typhus (Tsutsugamushi disease)
chemokines
rickettsiosis
chemokine receptor (CCR2)
interstitial pneumonia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.670219/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.670219/full

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