A novel function of RIP1 in postnatal development and immune homeostasis by protecting against RIP3-dependent necroptosis and FADD-mediated apoptosis

A novel function of RIP1 in postnatal development and immune homeostasis by protecting against RIP3-dependent necroptosis and FADD-mediated apoptosis

RIP1 is an adaptor kinase originally identified as being able to associate with TNFR1 and Fas, and is later shown to be involved in signaling induced by TLRs. Major signaling pathways regulated by RIP1 include necroptosis, apoptosis, and pro-survival/inflammation NF-B activation. Previous studies...

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Bibliographic Details
Main Authors: John eDowling, Anirudh eNair, Jianke eZhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Apoptosis
Immune homeostasis
mouse development
necroptosis
programmed cell death (PCD)
Online Access:http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00012/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fcell.2015.00012/full

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