Scap is required for sterol synthesis and crypt growth in intestinal mucosa[S]

Scap is required for sterol synthesis and crypt growth in intestinal mucosa[S]

SREBP cleavage-activating protein (Scap) is an endoplasmic reticulum membrane protein required for cleavage and activation of sterol regulatory element-binding proteins (SREBPs), which activate the transcription of genes in sterol and fatty acid biosynthesis. Liver-specific loss of Scap is well tole...

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Bibliographic Details
Main Authors: Matthew R. McFarlane, Mary Jo Cantoria, Albert G. Linden, Brandon A. January, Guosheng Liang, Luke J. Engelking
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Journal of Lipid Research
Subjects:
SREBP cleavage-activating protein
nuclear receptors/ sterol regulatory element-binding protein
cholesterol/biosynthesis
fatty acid/synthesis
organoid, intestine
gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520355334

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http://www.sciencedirect.com/science/article/pii/S0022227520355334

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