Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer

Notch and NF-κB: Coach and Players of Regulatory T-Cell Response in Cancer

The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-κB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions. This review focuses on how the multilayered crosstalk b...

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Bibliographic Details
Main Authors: Francesca Ferrandino, Paola Grazioli, Diana Bellavia, Antonio Francesco Campese, Isabella Screpanti, Maria Pia Felli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
Notch
NF-κB
regulatory T cells
Foxp3
cancer
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02165/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02165/full

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