CpG-island fragments from the <it>HNRPA2B1</it>/<it>CBX3 </it>genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells

CpG-island fragments from the <it>HNRPA2B1</it>/<it>CBX3 </it>genomic locus reduce silencing and enhance transgene expression from the hCMV promoter/enhancer in mammalian cells

<p>Abstract</p> <p>Background</p> <p>The <it>hCMV </it>promoter is very commonly used for high level expression of transgenes in mammalian cells, but its utility is hindered by transcriptional silencing. Large genomic fragments incorporating the CpG island r...

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Bibliographic Details
Main Authors: Irvine Alistair, Antoniou Michael, Simpson David, Griffiths Mark, Mulcahy Tony, Mustoe Tracey, Williams Steven, Mountain Andrew, Crombie Robert
Format: Article
Language:English
Published: BMC 2005-06-01
Series:BMC Biotechnology
Online Access:http://www.biomedcentral.com/1472-6750/5/17

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http://www.biomedcentral.com/1472-6750/5/17

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