Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease

Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease

<p>Abstract</p> <p>Background</p> <p>Neurotrophins and their receptors regulate several aspects of the developing and mature nervous system, including neuronal morphology and survival. Neurotrophin receptors are active in signaling endosomes, which are organelles that p...

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Bibliographic Details
Main Authors: Cabeza Carolina, Figueroa Alicia, Lazo Oscar M, Galleguillos Carolina, Pissani Claudia, Klein Andrés, Gonzalez-Billault Christian, Inestrosa Nibaldo C, Alvarez Alejandra R, Zanlungo Silvana, Bronfman Francisca C
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Molecular Neurodegeneration
Subjects:
NGF
Endosomes
Cholesterol
Niemann-Pick type C1
cholinergic system
PC12
Online Access:http://www.molecularneurodegeneration.com/content/7/1/11

Internet

http://www.molecularneurodegeneration.com/content/7/1/11

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