Phenotypic Changes on Mycobacterium Tuberculosis-Specific CD4 T Cells as Surrogate Markers for Tuberculosis Treatment Efficacy

Phenotypic Changes on Mycobacterium Tuberculosis-Specific CD4 T Cells as Surrogate Markers for Tuberculosis Treatment Efficacy

Background: The analysis of phenotypic characteristics on Mycobacterium tuberculosis (MTB)-specific T cells is a promising approach for the diagnosis of active tuberculosis (aTB) and for monitoring treatment success. We therefore studied phenotypic changes on MTB-specific CD4 T cells upon anti-tuber...

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Main Authors: Mohamed I. M. Ahmed, Nyanda E. Ntinginya, Gibson Kibiki, Bariki A Mtafya, Hadija Semvua, Stellah Mpagama, Charles Mtabho, Elmar Saathoff, Kathrin Held, Rebecca Loose, Inge Kroidl, Mkunde Chachage, Ulrich von Both, Antelmo Haule, Anna-Maria Mekota, Martin J. Boeree, Stephen H. Gillespie, Michael Hoelscher, Norbert Heinrich, Christof Geldmacher
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
TAM-TB assay
tuberculosis
treatment monitoring
Mycobacterium tuberculosis-specific T cells
serial sputum culture
biomarker
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02247/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02247/full

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