BRD4 inhibition for the treatment of pathological organ fibrosis [version 1; referees: 2 approved]

Fibrosis is defined as excess deposition of extracellular matrix, resulting in tissue scarring and organ dysfunction. It is estimated that 45% of deaths in the developed world are due to fibrosis-induced organ failure. Despite the well-accepted role of fibrosis in the pathogenesis of numerous diseas...

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Bibliographic Details
Main Authors: Matthew S. Stratton, Saptarsi M. Haldar, Timothy A. McKinsey
Format: Article
Language:English
Published: F1000 Research Ltd 2017-06-01
Series:F1000Research
Subjects:
Online Access:https://f1000research.com/articles/6-1015/v1