Induction of multiple myeloma cancer stem cell apoptosis using conjugated anti-ABCG2 antibody with epirubicin-loaded microbubbles

Induction of multiple myeloma cancer stem cell apoptosis using conjugated anti-ABCG2 antibody with epirubicin-loaded microbubbles

Abstract Background Multiple myeloma (MM) currently remains largely incurable. Cancer stem cells (CSCs) are believed to be responsible for drug resistance and eventual relapse. In this study, we exploited a novel agent to evaluate its inhibitory effect on MM CSCs. Methods Epirubicin (EPI)-loaded lip...

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Bibliographic Details
Main Authors: Fangfang Shi, Miao Li, Jing Wang, Di Wu, Meng Pan, Mei Guo, Jun Dou
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Stem Cell Research & Therapy
Subjects:
Multiple myeloma
Cancer stem cells
Epirubicin
Microbubble
Ultrasound
Online Access:http://link.springer.com/article/10.1186/s13287-018-0885-2

Internet

http://link.springer.com/article/10.1186/s13287-018-0885-2

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