In the crosshairs: Visualizing lytic granules by high resolution microscopy and electrophysiology

In the crosshairs: Visualizing lytic granules by high resolution microscopy and electrophysiology

Cytotoxic T lymphocytes (CTLs) form an integral part of the adaptive immune system. Their main function is to eliminate bacteria- and virus-infected target cells by releasing perforin and granzymes (the lethal hit) contained within lytic granules, at the CTL-target cell interface (the immunological...

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Bibliographic Details
Main Authors: Varsha ePattu, Mahantappa eHalimani, Min eMing, Claudia eSchirra, Ulrike eHahn, Hawraa eBzeih, Hsin-Fang eChang, Lisa eWeins, Elmar eKrause, Jens eRettig
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-11-01
Series:Frontiers in Immunology
Subjects:
SNARE Proteins
Cytotoxic T Cells
lytic granules
TIRFM
structured illumination microscopy
correlative light and electron microscopy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00411/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00411/full

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