Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility

Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs From Penicillium astrolabium Reveals an Extraordinary NRPS Flexibility

Asperphenamate is a small peptide natural product that has gained much interest due to its antitumor activity. In the recent years numerous bioactive synthetic asperphenamate analogs have been reported, whereas only a handful of natural analogs either of microbial or plant origin has been discovered...

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Bibliographic Details
Main Authors: Karolina Subko, Xinhui Wang, Frederik H. Nielsen, Thomas Isbrandt, Charlotte H. Gotfredsen, Maria C. Ramos, Thomas Mackenzie, Francisca Vicente, Olga Genilloud, Jens C. Frisvad, Thomas O. Larsen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Microbiology
Subjects:
natural product discovery
mass spectrometry
filamentous fungi
asperphenamate
amino acid incorporation
biological activity
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2020.618730/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2020.618730/full

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