Influence of Genetic Admixture Components on CYP3A5*3 Allele-Associated Hypertension in Amerindian Populations From Northwest Mexico

Influence of Genetic Admixture Components on CYP3A5*3 Allele-Associated Hypertension in Amerindian Populations From Northwest Mexico

CYP3A5 metabolizes endogenous substrates and ~30% of prescription drugs. The CYP3A5 gene contains an active CYP3A5*1 allele, and a non-functional version, the CYP3A5*3 (rs776746), with consequences for drug therapeutic responses and side effects. Both CYP3A5*1 and *3 have been associated with hypert...

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Bibliographic Details
Main Authors: Carlos Galaviz-Hernández, Blanca P. Lazalde-Ramos, Ismael Lares-Assef, Alejo Macías-Salas, Margarita A. Ortega-Chavez, Héctor Rangel-Villalobos, Martha Sosa-Macías
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
CYP3A5
polymorphisms
Amerindian
Mexican
hypertension
ancestry
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00638/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00638/full

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