Carnosine Supplementation Enhances Post Ischemic Hind Limb Revascularization

Carnosine Supplementation Enhances Post Ischemic Hind Limb Revascularization

High (millimolar) concentrations of the histidine containing dipeptide – carnosine (β-alanine-L-histidine) are present in the skeletal muscle. The dipeptide has been shown to buffer intracellular pH, chelate transition metals, and scavenge lipid peroxidation products; however, its role in protecting...

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Bibliographic Details
Main Authors: Adjoa A. Boakye, Deqing Zhang, Luping Guo, Yuting Zheng, David Hoetker, Jingjing Zhao, Dheeraj Kumar Posa, Chin K. Ng, Huaiyu Zheng, Amit Kumar, Vijay Kumar, Michael F. Wempe, Aruni Bhatnagar, Daniel J. Conklin, Shahid P. Baba
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Physiology
Subjects:
angiogenesis
Flk-1+/Sca-1+ cells
hind limb ischemia
HIF-1α
iron chelation
4-hydroxy-nonenal
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00751/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.00751/full

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