Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases

Low-dose IL-2 expands CD4+ regulatory T cells with a suppressive function in vitro via the STAT5-dependent pathway in patients with chronic kidney diseases

Background: Patients with chronic kidney disease (CKD) often have CD4+ regulatory T cells (Tregs) dysfunction and chronic inflammation. We aim to investigate the effect, function, and related mechanism of low-dose IL-2 on CD4+ regulatory T cells expansion in vitro from patients with CKD. Methods: A...

Full description

Bibliographic Details
Main Authors: Yuanyuan Li, Xueyong Liu, Wei Wang, Shaohua Wang, Jianchun Zhang, Song Jiang, Yang Wang, Liping Li, Jinghua Li, Youkang Zhang, Haichang Huang
Format: Article
Language:English
Published: Taylor & Francis Group 2018-10-01
Series:Renal Failure
Subjects:
Chronic kidney disease
glomerulonephritis
cytokines
lymphocytes
signaling
Online Access:http://dx.doi.org/10.1080/0886022X.2018.1456462

Internet

http://dx.doi.org/10.1080/0886022X.2018.1456462

Similar Items