Improving the Solubilization and Bioavailability of Arbidol Hydrochloride by the Preparation of Binary and Ternary β-Cyclodextrin Complexes with Poloxamer 188

Improving the Solubilization and Bioavailability of Arbidol Hydrochloride by the Preparation of Binary and Ternary β-Cyclodextrin Complexes with Poloxamer 188

In the current study, the effect of poloxamer 188 on the complexation efficiency and dissolution of arbidol hydrochloride (ADL), a broad-spectrum antiviral agent, with β-cyclodextrin (β-CD) was investigated. Phase solubility studies confirmed a stoichiometry of a 1:1 ratio for both ADL:β-CD and ADL/...

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Bibliographic Details
Main Authors: Md. Khalid Anwer, Muzaffar Iqbal, Mohammad Muqtader Ahmed, Mohammed F Aldawsari, Mohd Nazam Ansari, Essam Ezzeldin, Nasr Y Khalil, Raisuddin Ali
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
arbidol
β-cyclodextrin
poloxamer 188
ternary complex
solubilization
bioavailability
Online Access:https://www.mdpi.com/1424-8247/14/5/411

Internet

https://www.mdpi.com/1424-8247/14/5/411

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