IRE1α Is a Therapeutic Target for Cystic Fibrosis Airway Inflammation

IRE1α Is a Therapeutic Target for Cystic Fibrosis Airway Inflammation

New anti-inflammatory treatments are needed for CF airway disease. Studies have implicated the endoplasmic reticulum stress transducer inositol requiring enzyme 1α (IRE1α) in CF airway inflammation. The activation of IRE1α promotes activation of its cytoplasmic kinase and RNase, resulting in mRNA sp...

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Bibliographic Details
Main Authors: Emily A. Hull-Ryde, John T. Minges, Mary E. B. Martino, Takafumi Kato, Jacqueline L. Norris-Drouin, Carla M. P. Ribeiro
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
cystic fibrosis
airway epithelia
airway inflammation
cytokine
unfolded protein response
inositol requiring enzyme 1α
Online Access:https://www.mdpi.com/1422-0067/22/6/3063

Internet

https://www.mdpi.com/1422-0067/22/6/3063

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