Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G

Oxidative Stress Impairs Cell Death by Repressing the Nuclease Activity of Mitochondrial Endonuclease G

Endonuclease G (EndoG) is a mitochondrial protein that is released from mitochondria and relocated into the nucleus to promote chromosomal DNA fragmentation during apoptosis. Here, we show that oxidative stress causes cell-death defects in C. elegans through an EndoG-mediated cell-death pathway. In...

Full description

Bibliographic Details
Main Authors: Jason L.J. Lin, Akihisa Nakagawa, Riley Skeen-Gaar, Wei-Zen Yang, Pei Zhao, Zhe Zhang, Xiao Ge, Shohei Mitani, Ding Xue, Hanna S. Yuan
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Cell Reports
Subjects:
endonuclease G
apoptosis
nuclease
mitochondria dysfunction
crystal structure
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716307033

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716307033

Similar Items