Induction of DNA damage, apoptosis and cell cycle perturbation mediate cytotoxic activity of new 5-aminosalicylate–4-thiazolinone hybrid derivatives

Induction of DNA damage, apoptosis and cell cycle perturbation mediate cytotoxic activity of new 5-aminosalicylate–4-thiazolinone hybrid derivatives

Modulation of several targets in cancer cells enhances the effect of anti-cancer drugs. This can be achieved by using combinations of anti-cancer drugs or by designing new drugs with novel pharmacophore structures that target different molecules within cancer cells. We developed a panel of such comp...

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Bibliographic Details
Main Authors: Wafaa S Ramadan, Ekram M Saleh, Varsha Menon, Cijo George Vazhappilly, Hajjaj H.M. Abdu-Allah, Abdel-Nasser A. El-Shorbagi, Wael Mansour, Raafat El-Awady
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
5-aminosalicylate–4-thiazolinone
DNA damage
Cell cycle
Apoptosis
DNA damage response machinery
Signal transducers
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332220307642

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http://www.sciencedirect.com/science/article/pii/S0753332220307642

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