The stemness of hepatocytes is maintained by high levels of lipopolysaccharide via YAP1 activation

The stemness of hepatocytes is maintained by high levels of lipopolysaccharide via YAP1 activation

Abstract Background The liver possesses a powerful regeneration ability, which is correlated with the stemness of hepatocytes in the portal vein (PV). However, the mechanism underlying the maintenance of hepatocyte stemness has not been elucidated. Here, we hypothesized that high levels of lipopolys...

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Bibliographic Details
Main Authors: Changchun Shao, Xue Yang, Yingying Jing, Xiaojuan Hou, Yihua Huang, Chen Zong, Lu Gao, Wenting Liu, Jinghua Jiang, Fei Ye, Junxia Shi, Qiudong Zhao, Rong Li, Xiaoren Zhang, Lixin Wei
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Stem Cell Research & Therapy
Subjects:
Lipopolysaccharide
Toll-like receptor 4
Hepatocytes
Stemness maintenance
Yes-associated protein 1
Online Access:https://doi.org/10.1186/s13287-021-02421-7

Internet

https://doi.org/10.1186/s13287-021-02421-7

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