Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles

Cytosolic delivery of nucleic acids: The case of ionizable lipid nanoparticles

Abstract Ionizable lipid nanoparticles (LNPs) are the most clinically advanced nano‐delivery system for therapeutic nucleic acids. The great effort put in the development of ionizable lipids with increased in vivo potency brought LNPs from the laboratory benches to the FDA approval of patisiran in 2...

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Bibliographic Details
Main Authors: Michele Schlich, Roberto Palomba, Gabriella Costabile, Shoshy Mizrahy, Martina Pannuzzo, Dan Peer, Paolo Decuzzi
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Bioengineering & Translational Medicine
Subjects:
endosomal escape
intracellular delivery
ionizable lipids
LNPs
mRNA
RNA delivery
Online Access:https://doi.org/10.1002/btm2.10213

Internet

https://doi.org/10.1002/btm2.10213

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