Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells

Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells

We have developed a robust, Good Manufacturing Practice‐compatible differentiation protocol capable of producing scalable quantities of red blood cells (RBCs) from human pluripotent stem cells (hPSCs). However, translation of this protocol to the clinic has been compromised because the RBCs produced...

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Bibliographic Details
Main Authors: Melany Jackson, Rui Ma, A. Helen Taylor, Richard A. Axton, Jennifer Easterbrook, Maria Kydonaki, Emmanuel Olivier, Lamin Marenah, Edouard G. Stanley, Andrew G. Elefanty, Joanne C. Mountford, Lesley M. Forrester
Format: Article
Language:English
Published: Wiley 2016-08-01
Series:Stem Cells Translational Medicine
Subjects:
CD34+
Cell surface markers
Colony formation
Differentiation
Electroporation
Embryonic stem cells
Online Access:https://doi.org/10.5966/sctm.2015-0324

Internet

https://doi.org/10.5966/sctm.2015-0324

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