Hydrophilic Linear Peptide with Histidine and Lysine Residues as a Key Factor Affecting Antifungal Activity

Hydrophilic Linear Peptide with Histidine and Lysine Residues as a Key Factor Affecting Antifungal Activity

Increases in the numbers of immunocompromised patients and the emergence of drug-resistance fungal pathogens have led to the need for new, safe, efficacious antifungal agents. In this study, we designed a histidine-lysine-lysine (HKK) motif and synthesized six HKK peptides with repetitions of the mo...

Full description

Bibliographic Details
Main Authors: Seong-Cheol Park, Jin-Young Kim, Eun-Ji Kim, Gang-Won Cheong, Yongjae Lee, Wonkyun Choi, Jung Ro Lee, Mi-Kyeong Jang
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
antimicrobial peptide
drug-resistance
antifungal activity
reactive oxygen species
apoptosis
Online Access:https://www.mdpi.com/1422-0067/19/12/3781

Internet

https://www.mdpi.com/1422-0067/19/12/3781

Similar Items