Clinical-grade cryopreserved doxorubicin-loaded platelets: role of cancer cells and platelet extracellular vesicles activation loop

Clinical-grade cryopreserved doxorubicin-loaded platelets: role of cancer cells and platelet extracellular vesicles activation loop

Abstract Background Human platelets (PLT) and PLT-extracellular vesicles (PEV) released upon thrombin activation express receptors that interact with tumour cells and, thus, can serve as a delivery platform of anti-cancer agents. Drug-loaded nanoparticles coated with PLT membranes were demonstrated...

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Bibliographic Details
Main Authors: Yu-Wen Wu, Cheng-Chain Huang, Chun Austin Changou, Long-Sheng Lu, Hadi Goubran, Thierry Burnouf
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Journal of Biomedical Science
Subjects:
Cryopreserved platelet
Tissue factor
Cancer
Doxorubicin
Platelet extracellular vesicles
Drug delivery
Online Access:http://link.springer.com/article/10.1186/s12929-020-00633-2

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http://link.springer.com/article/10.1186/s12929-020-00633-2

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