Divergent Asymmetric Total Synthesis of All Four Pestalotin Diastereomers from (<i>R</i>)-Glycidol

Divergent Asymmetric Total Synthesis of All Four Pestalotin Diastereomers from (<i>R</i>)-Glycidol

All four chiral pestalotin diastereomers were synthesized in a straightforward and divergent manner from common (<i>R</i>)-glycidol. Catalytic asymmetric Mukaiyama aldol reactions of readily-available bis(TMSO)diene (Chan&#8217;s diene) with (<i>S</i>)-2-benzyloxyhexanal...

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Bibliographic Details
Main Authors: Mizuki Moriyama, Kohei Nakata, Tetsuya Fujiwara, Yoo Tanabe
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
asymmetric total synthesis
divergent synthesis
pyran-2-one
pestalotin
epipestalotin
asymmetric mukaiyama aldol reaction
hetero diels-alder reaction
mitsunobu inversion
chan’s diene
brassard’s diene
Online Access:https://www.mdpi.com/1420-3049/25/2/394

Internet

https://www.mdpi.com/1420-3049/25/2/394

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