Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.

Gasdermin-D and Caspase-7 are the key Caspase-1/8 substrates downstream of the NAIP5/NLRC4 inflammasome required for restriction of Legionella pneumophila.

Inflammasomes are cytosolic multi-protein complexes that detect infection or cellular damage and activate the Caspase-1 (CASP1) protease. The NAIP5/NLRC4 inflammasome detects bacterial flagellin and is essential for resistance to the flagellated intracellular bacterium Legionella pneumophila. The ef...

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Bibliographic Details
Main Authors: Augusto V Gonçalves, Shally R Margolis, Gustavo F S Quirino, Danielle P A Mascarenhas, Isabella Rauch, Randilea D Nichols, Eduard Ansaldo, Mary F Fontana, Russell E Vance, Dario S Zamboni
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007886

Internet

https://doi.org/10.1371/journal.ppat.1007886

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